CHEMOTHERAPEUTIC INVESTIGATIONS WITH ROUS SARCOMA VIRUS
نویسندگان
چکیده
منابع مشابه
Strains of Rous Sarcoma Virus
SHIPMAN, CHARLES, JR. (Indiana University School of Medicine, Indianapolis), AND ALVIN S. LEVINE. Selective response of the Japanese quail to various strains of Rous sarcoma virus. J. Bacteriol. 92:161-163. 1966.-The Bryan "high-titer," CarrZilber, Harris, Prague, Schmidt-Ruppin, and "29" strains of Rous sarcoma virus were used to initiate tumors in the Japanese quail (Coturnix coturnix japonic...
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We have studied the pattern of glycoprotein synthesis in two nonconditional mutants of Rous sarcoma virus. One mutant, SE33, produces no viral particles but synthesizes Pr92M', which is cleaved intracellularly to mature glycoproteins. The second mutant, SE521, encodes a gPr92"nv which is not cleaved to gp85 or gp37 and therefore produces virions with the phenotype of Bryan RSV(-) or NY8. Neithe...
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The discovery of Rous sarcoma virus, which was reported by Peyton Rous in the Journal of Experimental Medicine 100 years ago, opened the field of tumor virology. It showed that some cancers have infectious etiology, led to the discovery of oncogenes, and laid the foundation for the molecular mechanisms of carcinogenesis. Rous spent his entire research career at The Rockefeller Institute, and he...
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A procedure for obtaining a high percentage of Rous sarcoma virus-infected cells in cultures is described. Approximately 50% of the cells were infected by the 3rd day, a» determined by infec tive center assay. Vims assayed 24 hr after infection showed only IO1 infective particles/ml of supernatant fluid. Maximal titers ranged between IO5 and IO6infective particles/ml from the 5th day on. Cultu...
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An efficient and quantitative assay for infectious Rous sarcoma virus and reticuloendotheliosis virus DNAs is described. The specific infectivities of viral DNA corresponded to one infectious unit per 10(5) to 10(6) viral DNA molecules. Infection with viral DNA followed one-hit kinetics. The minimal size of infectious Rous sarcoma virus DNA was approximately 6 million daltons, whereas the minim...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1952
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1952.tb01323.x